Oxford University, Structural Bioinformatics & Computational Biochemistry Unit
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A. Caroline E. Dahl



Structural Bioinformatics and Computational Biochemistry Unit
Dept. of Biochemistry
University of Oxford
South Parks Road
Oxford
OX1 3QU
UK

Telephone: +44 (0) 1865 613 304
Fax: +44 (0) 1865 613 238

e-mail: caroline.dahl AT dtc.ox.ac.uk
division line

Membrane protein mechanotransduction


Background

I left Sweden for a degree in Neuroscience, but quickly found that the real action takes place at the cell membrane. In the flexible and forgiving undergraduate environment at the University of Edinburgh, I migrated from Neuroscience to Chemistry, completed internships in both Stockholm and Edinburgh stem cell labs, and was part of the Edinburgh University team at the MIT Genetically Engineered Machine competition, before landing in structural biochemistry. I graduated with Honours in Biochemistry in 2008, and entered Oxford University's Doctoral Training Centre on an EPSRC scholarship.

I joined the Sansom group as a D.Phil student in 2010 after completing three 10-week projects in physics, bioengineering/mathematics and optogenetics.


Research

I use coarse-grained and atomistic GROMACS MD to investigate the conformational events that follow physiological membrane deformation.

I am also interested in protein structure representation and analysis, where I extend available visualisation techniques for proteins. If you wish to be kept informed about when Bendix is published and made publicly available, please send me an email and I will let you know asap. Thank you.


Research output

Dahl ACE, Chavent, M and Sansom, MSP (2012) Analysing helix flexibility in membrane proteins using Bendix. Annual US Biophysical Society conference in San Diego (poster presentation) Abstract

Dahl ACE, Chavent, M and Sansom, MSP (2011) Visualization and Analysis of Helix Flexibility Using Bendix. Young Modeller Forum, London (poster presentation)

Dahl ACE, Chavent, M and Sansom, MSP (2011) Bendix: a VMD plugin that cartoons proteins and characterizes helix conformation. OXION: Ion Channels and Disease Initiative Day (poster presentation)

Dahl ACE and Thompson MS (2011) 5.18 - Mechanobiology of Bone, In: Comprehensive Biotechnology (Second Edition) Volume editor Moo-Young M, Academic Press, Burlington, pp 217-236 Abstract

Dahl ACE (2011) Functional protein visualization. UK Systems Biology inter-DTC conference, University of Manchester (talk)

Dahl ACE and Thompson M (2010) Bone mechanosensation. Systems Biology InterDTC Conference 2010, University of Warwick (poster presentation)

Click below to download a Flash image overview of what happens to osteocytes upon mechanical impact (when you take a step) !
Mouse over molecule abbreviatons to view their full names, and toggle between pre-mechanical impact and during impact, which features suggested reaction pathways and changes to cell physiology in response to mechanical stimulus.
For more information, read the review here.

Download bone cell Flash file.

Dahl ACE (2008) A computational epigenetics study of nucleosome positioning with respect to CpG islands in the human and mouse genomes. Dissertation presented to University of Edinburgh in partial fulfillment of requirements for the degree of BSc (Hons Biochemistry).

Dahl ACE, Gerosa L, Hollingshead S, Marshall A, Ravindranath P, Rokicki J, Wang X, Yin D, Elfick A, French C and Ma H (2008) University of Edinburgh iGEM 2007 projects: A cell division detector, and self-flavouring yoghurt. BioSysBio 2008, Imperial College London (poster presentation)

Dahl ACE, Gerosa L, Hollingshead S, Marshall A, Ravindranath P, Rokicki J, Wang X, Yin D, Elfick A, French C and Ma H (2007) The Cell Division PoPper, and Self Flavouring Yoghurt. iGEM 2007, MIT Cambridge MA (poster presentation and talk). See the website for details.

Dahl ACE, Gerosa L, Hollingshead S, Marshall A, Ravindranath P, Rokicki J, Wang X, Yin D, Elfick A, French C and Ma H (2007) The 2007 Edinburgh iGEM team submissions. ESRC Genomics Policy and Research Forum, Edinburgh (talk)
Last updated February 2012