Dr. Philip W. Fowler

H-index

My H-index is 11. For the current value please see Google Scholar or WoK. I also have a Mendeley profile

Publications

* joint first author

17. Solcan N, Kwok J, Fowler PW, Cameron AD, Drew D, Iwata S and Newstead S Structural insight into the role of salt bridge interactions within the POT family of oligopeptide transporters (2012) accepted for publication in EMBO J.

16. Newstead S, Drew D, Cameron AD, Postis VLG, Xiobing X, Fowler PW, Ingram, JC, Carpenter EP, Sansom MSP, McPherson MJ, Baldwin SA and Iwata S Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters PepT1 and PepT2 (2011) EMBO J. 310 417-426 doi:10.1038/emboj.2010.309

15. Paynter JJ, Andres-Enguix I, Fowler PW, Tottey S, Cheng W, Enkvetchakul D, Bavro VN, Kusakabe Y, Sansom MSP, Robinson NJ, Nichols CG and Tucker SJ Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains (2010) J Biol Chem. 285 40754-40761 doi:10.1074/jbc.M110.175687

14. Newstead S*, Fowler PW*, Bilton P*, Carpenter E, Sadler PJ, Campopiano DJ, Sansom MSP and Iwata S Insights into how nucleotide-binding domains power ABC transport (2009) Structure 17 1213-1222 doi:10.1016/j.str.2009.07.009

13. Abad E, Reingruber J, Fowler PW and Sansom MSP A Novel Rate Theory Approach to Transport in Ion Channels (2008) In AIP Conference Proceedings, Volume 1102 (Theory and Applications of Computational Chemistry), pages 236-243 doi:10.1063/1.3108380

12. Tai K, Fowler PW, Mokrab Y, Stansfeld PJ and Sansom MSP Molecular Modeling and Simulation Studies of Ion Channel Structures, Dynamics and Mechanisms (2008) Chapter 12 in Methods in Cell Nano Biology Volume 90 (edited by Bhanu P. Jena). 233-265

11. Psachoulia E, Fowler PW, Bond PJ and Sansom MSP Helix-Helix interactions in membrane proteins: Coarse grained simulations of Glycophorin helix dimerization (2008) Biochemistry. 47 10503-10512 doi:10.1021/bi800678t

10. Fowler PW, Tai K and Sansom MSP. The selectivity of K+ ion channels: testing the hypotheses (2008) Biophys. J. 95 5062-5072 doi:10.1529/biophysj.108.132035

9. Rapedius M, Paynter JJ, Fowler PW , Sansom MSP, Tucker SJ and Baukrowitz T Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-bonding at the helix-bundle crossing (2007) Channels. 1 327-330 link

8. Rapedius M, Fowler PW, Sansom MSP, Tucker SJ and Baukrowitz T. H-Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels. (2007) Neuron. 55 602-614 doi:10.1016/j.neuron.2007.07.026

7. Fowler PW, Geroult S, Jha S, Waksman G and Coveney PV. Rapid, accurate and precise calculation of relative binding affinities for the SH2 domain using a computational grid. (2007) J. Chem. Theo. Comp. 3 1193-1202 doi:10.1021/ct6003017

6. Fowler PW*, Balali-Mood K*, Deol SS, Coveney PV and Sansom MSP. Monotopic proteins and lipid bilayers: a comparative study. (2007) Biochemistry 46 3108-3115 doi:10.1021/bi602455n

5. Fowler PW and Coveney PV. A computational protocol for the integration of the monotopic protein prostaglandin H2 synthase into a phospholipid bilayer. (2006) Biophys. J. 91 401-410 doi:10.1529/biophysj.105.077784

4. Fowler PW, Jha S and Coveney PV. Grid-based steered thermodynamic integration accelerates the calculation of binding affinities/free energies. (2005) Phil. Trans. R. Soc. Lond. A 363(1833) 1999-2015 doi:10.1098/rsta.2005.1625

3. Giordanetto F, Fowler PW, Saqi M and Coveney PV. Large scale molecular dynamics of native and mutant dihydroptreoate synthase-sulphanilamide complexes suggests the molecular basis for dihyropteroate synthase drug resistance (2005) Phil. Trans. R. Soc. Lond. A 363(1833) 2055-2073 doi:10.1098/rsta.2005.1629

2. Fowler PW and Coveney PV. Modelling biological complexity: a physical scientist's perspective (2005) J. R. Soc. Interface 2(4) 267-280 doi:10.1098/rsif.2005.0045

1. Fowler PW, Jha S, Coveney PV and Wan S. Exact calculation of peptide-protein binding energies by steered thermodynamic integration using high performance computing grids (2004) In Proceedings of the UK e-Science All Hands Meeting download