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Dr Heidi Koldsø
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Dr Heidi Koldsø |
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Structural Bioinformatics and Computational Biochemistry Unit Dept. of Biochemistry University of Oxford South Parks Road Oxford OX1 3QU U.K. Telephone: 01865 613304 Fax: 01865 613238 e-mail: heidi.koldsoe@bioch.ox.ac.uk |
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Coarse-grained and atomistic molecular dynamics simulations of signaling somplexes | |
Background |
I obtained my BSc, MSc and PhD degrees in Medicinal Chemistry from Aarhus University, Aarhus, Denmark. My PhD research was mainly focused on homology modelling, induced fit docking and molecular dynamics simulations of human monoamine transporters.
Additionally, effects of post-translational modfications, pH and pathogenic mutations on two amyloid proteins (Prion and FAS1-4 domain of TGFBIp) were explored by molecuar dynamics simulations. |
Research |
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My current research is focused on the properties of gp130 cytokine receptor complexes by coarse-grained and atomistic molecular dynamics simulations.
The work is supported by the Alfred Benzon Foundation
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Publications |
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*Equal contributions Unbiased Simulations Reveal the Inward-Facing Conformation of the Human Serotonin Transporter and Na+ Release Koldsø, H.; Noer, P.; Grouleff, J.; Autzen, H. E. ; Sinning, S.;Schiøtt, B. PLoS. Comp. Biol. (2011) 7(10): e1002246 DOI:10.1371/journal.pcbi.1002246 Link Synthesis of uronic-Noeurostegine - a potent bacterial β-glucuronidase Rasmussen, T. S.; Koldsø, H.; Nakagawa, S.; Kato, A.;Schiøtt, B.; Jensen, H. H. Org. Biomol. Chem. (2011) 9, 7807-7813 DOI:10.1039/C1OB06038D Link The Two enatiomers of Citalopram Bind to the Human Serotonin Transporter in Reversed Orientations Koldsø, H.; Severinsen, K.; Tran, T. T.; Celik, L.; Jensen, H. H.; Wiborg, O.; Schiøtt, B.; Sinning, S. J. Am. Chem. Soc. (2010) 132, 1311-1322 DOI:10.1021/ja906923j Link Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter Sinning, S.*; Musgaard, M.*; Jensen, M.*; Severinsen, K.*; Celik, L.*; Koldsø, H.*; Meyer, T.; Bols, M.; Jensen, H. H.; Schiøtt, B.; Wiborg, O. J. Biol. Chem. (2010) 285, 8363-8374. DOI: 10.1074/jbc.M109.045401 Link | |
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| Last updated 16 Feb 2012 |