Oxford University, Structural Bioinformatics & Computational Biochemistry Unit
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Tyler Reddy

Structural Bioinformatics and Computational Biochemistry Unit
Dept. of Biochemistry
University of Oxford
South Parks Road
Oxford
OX1 3QU
U.K.

Telephone: 01865 613304
Fax: 01865 613238

e-mail: tyler.reddy@bioch.ox.ac.uk
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Background
I completed my BSc Honours and PhD degrees in Biochemistry & Molecular Biology at Dalhousie University in Halifax, N.S., Canada. My undergraduate research interests spanned murine developmental biology and racemase enzymology. My graduate training was primarily focused on membrane protein NMR spectroscopy, NMR spin relaxation experiments, and coarse-grained molecular dynamics simulations of membrane proteins.


Research
My current focus is on the study of very large biomolecular systems by coarse-grained MD simulations. My work is supported by the Canadian Institutes of Health Research.

Publications
*Equal contributions
  1. Reddy, T., Li, X., Fliegel, L., Sykes, B.D., and Rainey, J.K. (2010) Correlating structure, dynamics, and function in transmembrane segment VII of the Na+/H+ exchanger isoform 1. Biochim Biophys Acta: Biomembranes. 1798: 94-104. [Pubmed]
  2. Reddy, T. and Rainey, J.K. (2010) Interpretation of biomolecular NMR spin relaxation parameters. Biochemistry and Cell Biology. 88: 131-142. [Pubmed]
  3. Langelaan, D.N., Bebbington, E.M., Reddy, T., and Rainey, J.K. (2009) Structural insight into G-protein coupled receptor binding by apelin. Biochemistry. 48: 537-548. [Pubmed]
  4. Reddy, T.*, Ding, J.*, Li, X., Sykes, B.D., Rainey, J.K., and Fliegel, L. (2008) Structural and Functional Characterization of Transmembrane Segment IX of the NHE1 Isoform of the Na+/H+ Exchanger. Journal of Biological Chemistry. 283: 22018-22030. [Pubmed] [PDB entry (2K3C)] [BMRB entry (15747)]
  5. Baguma-Nibasheka, M., Reddy, T., Abbas-Butt, A., and Kablar, B. (2006) Fetal ocular movements and retinal cell differentiation: analysis employing DNA microarrays. Histology and histopathology. 21: 1331-1337. [Pubmed]
  6. Reddy, T.*, Rot-Nikcevic, I.*, Downing, K.J., Belliveau, A.C., Hallgrímsson, B., Hall, B.K., and Kablar, B. (2006) Myf5-/-: MyoD-/- amyogenic fetuses reveal the importance of early contraction and static loading by striated muscle in mouse skeletogenesis. Development genes and evolution. 216: 1-9. [Pubmed]
  7. Reddy, T. and Kablar, B. (2004) Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5-/-:MyoD-/- and NT-3-/- embryos. Developmental Dynamics. 231: 683-692. [Pubmed]
Last updated 21 Nov 2011